LIPOGEMS® treatment: The regenerative effects of LIPOGEMS® therapy in patients with (degenerative) arthritis or musculoskeletal diseases have already been proven. The treatment can be carried out also on knees, ankles, hips and shoulders. Treatment results have shown clear improvement in the symptoms and substantial decrease in pain. In certain cases the implantation of protheses can be spared.
The procedure, patented in 2010, combines plastic surgery with regenerative medicine. This easily applicable technology has been developed to retrieve adipose tissues, process them within 20 minutes and re-implant them in the area to be cured. This innovative technology results in the creation of LIPOGEMS® rich in capillaries. During the process perivascular cells of pericytes in the capillaries are freed and transformed into stem cells.
Due to the antibacterial and anti-inflammatory features of LIPOGEMS® (LL 37 antibiotics), the healing process is accelerated. Lipogems consist of minimally modified, microfragmented adipose tissue thus increasing the the natural regenerative abilities of neighbouring tissues. Even complete recovery can be reached. Its clinical application in aesthetic treatments, orthopaedic and general surgery has shown promising results. The procedure has been applied without any problem in 7,000 cases worldwide so far.
The orthopaedic use of LIPOGEMS®
Stem cells retrieved via the emulsification of washed adipose tissue and then reinjected can transform into cells similar to their neighbouring cells, e.g. muscle, bone, tendon or ligament cells.
During the non-invasive and less traumatic process the amount of adipose tissue is taken with a thin needle and then transformed into millions of stem cells to be later applied in regenerative therapies. To make a quick comparison: 1 out of 100 fat cells includes a stem cell, while in bone marrow this rate is 100,000 : 1. The process is rapid and minimally invasive without including any enzimes, addititives or time-consuming laboratory procedures. Local or intravenous anaesthetics are sufficient, there is no need for putting the patient under general anaesthesia. The duration of hospital stay is substantially reduced.
Main indications for LIPOGEMS® Therapy
- Degenerative changes in joints and tendons
- Enthesopathies (i.e. tennis elbow, golf elbow, patella syndrome)
- Reconstruction of bone and cartilage tissue
LIPOGEMS® is a single-use, closed-system device licensed by FDA (Food and Drug Administration – USA) to process and re-inject fat. The non-expanded (avoiding enzime-driven laboratory cell reproduction) and micro-fractured (frittered) autologous adipose tissue can be applied in the cure of musculoskeletal diseases and aesthetic treatments.
LIPOGEMS® is a revolutionary method of utilising removed fat tissue while conserving its entire micro-environment with its regenerative abilities.
What is unique about LIPOGEMS®?
An important feature of the method is that – being an immediate physical and enzyme-free intervention – it protects the intact stromal vascular fractions (picture), the supportive pericytes and citokines besides the mesenchymal stem cells, as well as the connective issue matrix.
It has been proven that, as opposed to former scientific thinking, adipose tissue is a very dynamic and active biological tissue.
Who would have ever thought adipose tissue to be of such tremendous use! This information is still to be digested, however, it is a fact that adipose tissue has a curing effect in LIPOGEMS® treatments.
It includes not only mesenchymal stem cells (MSCs), but also growth factors, supportive cells, i.e. pericytes (right picture) and curing proteins, i.e. cytokines. (Cytokines are small molecular weight proteins essential in intercellular communication. Every cell with a nucleus produces cytokines, which influence the functioning of other cells. Without cytokines the stem cell would not know what to do!)
Today it is a scientific fact that adipose tissue includes cell types with naturally regenerative abilities. As a consequence, adipose tissue is an alternative to bone marrow concerning the extraction of cells.
A further advantage of adipose tissue is that – as no painful bone marrow transplantation is necessary – it is easily available at any ages and with almost no limits (as it is renewed rapidly). However, it is a problem that the critical cells and the cytokines are embedded in the fat matrix. Now, this is solved by LIPOGEMS®.
Fat can be dissolved in laboratory environment with the aid of enzymes and the cell types needed can be multiplied (poliferation). The process is time-consuming, expensive and does not always ensure the desired survival rate of the cells in other procedures as LIPOGEMS® does.
What is unique and revolutionary about LIPOGEMS® technology?
Fat undergoes a minimally invasive and enzyme-free treatment in a sterile device. This also means the gradual reduction of fat clusters in size and the removal of inflammatory oils, blood residue and other unwanted cell types.
All this can be reached with the help of exclusively physical interventions and various filters, which activate cells – similar to natural physical influences (e.g. kitchen accidents, fractures, bruises) – in order to obtain the regenerative effects immediately and on a wide spectrum. The extraction of the appropriate tissues is carried out in an airtight sterile saline solution, which provides circumstances very similar to the micro-environment of the inner human body and minimalises cell damage. As a consequence, the entire natural tissue environment can be kept and the regenerative effect maximalised.
It is important to note that LIPOGEMS® is not exclusively a stem cell therapy. It is a comprehensive regenerative treatment.
It is less known that if one injects stem cells on a wounded surface, the majority of these cells die. As mentioned earlier, the mesenchymal stem cells need the support of other cells and proteins to develop their curing and regenerative effect. As opposed to stem cell treatments, the major and unique advantages of LIPOGEMS® therapy are 1) the careful application of a regenerative environment entirely closed up in adipose tissue and 2) its precise injection. The main purpose of LIPOGEMS® technology is to utilize the naturally healing effect of tissues in numerous diseases, against musculoskeletal pain, or in aesthetic regenerative surgery.
What happens at a LIPOGEMS® treatment?
First of all, patient’s skin will be anesthetized with local anesthetics. Then follows the introduction of a thin and dull cannula into the adipose tissue and the infiltration of a combination of sterile saline solution and anesthetics. It takes about 15 minutes for the anesthetics to develop its effect. In sensitive patients or in certain treatments where it is justifiable, central analgesics, or even general anesthesia are applicable. Then, introducing a thin cannula to collect tissue, the liposuction aspiration procedure starts. It only takes a couple of minutes and it is practically painless. Depending on the area involved, 50-500 cm3 of adipose tissue will be removed. The collected fat will be immediately processed (i.e. chopped and reduced in volume). The autologous tissue (including only patient’s own cells) is derived with the patented LIPOGEMS® technology by keeping the entire tissue environment intact for optimal regenerative effect. The process takes 10-40 minutes depending on the amount of tissue needed. The result of the tissue selection – a golden and easily injectable liquid – can then be introduced into the area waiting for regeneration with the necessary technique. The total duration of a LIPOGEMS® treatment is about 45-120 minutes, whose major part is used for anasthetics and tissue selection.
The technology supported by an expert group on stem cell research including outstanding experts (e.g. Prof. Dr. Arnold Caplan, „father” of mesenchymal stem cells) has been introduced to numerous European countries and now it is also available in Hungary by Dr István Szabó and Dr Ernő Majzik praxisában.
Indications show broad applicability in the fields of curing and conservation:
- – Osteoarthrosis, cartilage and ligament injuries, other sport injuries, decreasing pain
- – Non-healing wounds, fistules
- – Urinary and faecal incontinence
The method can be applied with great success and effectiveness in beauty treatments and aesthetic surgery as well.
The therapy enables the remarkable regeneration and rejuvenation of face and hand skin. The treatment is minimally invasive and immediate, its positive effect can be seen instantly. It is recommended for the middle aged and the elderly who face adipose tissue weight loss and some tissue collapse as well as a loss in skin tone.
As a results of the therapy you get rejuvenated facial skin, regenerated shape of the face and increased tissue volume.
- – filling and regeneration of face and other body parts with patient’s own cells
- – treatment of scars and cicatrices
- – hair regeneration
- – breast and buttock enlargement
- – calf and hand aesthetics
A summary of the advantages of LIPOGEMS® treatment:
Patient’s own adipose tissue processed and re-injected without the risk of rejection
Local anaesthetics – patient may leave the surgery after treatment
No swellings or ecchymoses
Skin surface is nurtured and regenerated